Gene: BDNF

Alternate names for this Gene: ANON2|BULN2

Gene Summary: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.

Gene is located in Chromosome: 11

Location in Chromosome : 11p14.1

Description of this Gene: brain derived neurotrophic factor

Type of Gene: protein-coding

Gene: BDNF-AS

Alternate names for this Gene: ANTI-BDNF|BDNF|BDNF-AS1|BDNFAS|BDNFOS|NCRNA00049

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11p14.1

Description of this Gene: BDNF antisense RNA

Type of Gene: ncRNA

rs16917237 in BDNF;BDNF-AS gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

PMID 25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

rs16917237 in BDNF;BDNF-AS gene and Age at menopause PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

rs11030102 in BDNF;BDNF-AS gene and Body Weight PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

rs11030100 in BDNF;BDNF-AS gene and Body mass index PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

PMID 26961502 2016 Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 26604143 2016 Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.

PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 29273807 2018 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs11030104 in BDNF;BDNF-AS gene and Body mass index procedure PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

rs11030104 in BDNF;BDNF-AS gene and Finding of body mass index PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

rs6265 in BDNF;BDNF-AS gene and Hip circumference PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs1554931219 in BDNF;BDNF-AS gene and Muscle hypotonia PMID 18753648 2008 Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

PMID 28397838 2018 Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PMID 11579207 2001 Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.

PMID 21567907 2011 11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity.

PMID 19577647 2009 New insights into the role of brain-derived neurotrophic factor in synaptic plasticity.

PMID 23044507 2012 Highly penetrant alterations of a critical region including BDNF in human psychopathology and obesity.

rs10835211 in BDNF;BDNF-AS gene and Obesity PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

rs1554931219 in BDNF;BDNF-AS gene and Overgrowth PMID 23044507 2012 Highly penetrant alterations of a critical region including BDNF in human psychopathology and obesity.

PMID 21567907 2011 11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity.

PMID 11579207 2001 Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.

PMID 28397838 2018 Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PMID 18753648 2008 Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

PMID 19577647 2009 New insights into the role of brain-derived neurotrophic factor in synaptic plasticity.

rs7103411 in BDNF;BDNF-AS gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs11030104 in BDNF;BDNF-AS gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

PMID 20418890 2010 Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

rs6265 in BDNF;BDNF-AS gene and Smoking Behaviors PMID 22832964 2012 Genome-wide meta-analyses of smoking behaviors in African Americans.

PMID 20418890 2010 Genome-wide meta-analyses identify multiple loci associated with smoking behavior.

rs10835211 in BDNF;BDNF-AS gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11030108 in BDNF;BDNF-AS gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs61888762 in BDNF;BDNF-AS gene and body fat percentage (physical finding) PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs4517468 in BDNF;BDNF-AS gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.