Gene: BMP3

Alternate names for this Gene: BMP-3A

Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.21

Description of this Gene: bone morphogenetic protein 3

Type of Gene: protein-coding