Gene: BNC2
Alternate names for this Gene: BSN2|LUTO
Gene Summary: This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. This gene is also associated with susceptibility to adolescent idiopathic scoliosis.
Gene is located in Chromosome: 9
Location in Chromosome : 9p22.3-p22.2
Description of this Gene: basonuclin 2
Type of Gene: protein-coding
rs10756785 in
BNC2 gene and
Adolescent idiopathic scoliosis
PMID 30395268 2018 Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
PMID 26211971 2015 A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
rs3936215 in
BNC2 gene and
Asthma
PMID 24406073 2014 Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
PMID 25918132 2015 Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.
rs10962638 in
BNC2 gene and
Body Fat Distribution
PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
rs12335424 in
BNC2 gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.
rs10116857 in
BNC2 gene and
Body mass index
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
rs189669683 in
BNC2 gene and
Chronic Obstructive Airway Disease
PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
rs10810632 in
BNC2 gene and
Diabetes Mellitus, Insulin-Dependent
PMID 19875614 2010 A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
rs10756796 in
BNC2 gene and
Eczema
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs2153271 in
BNC2 gene and
Freckles
PMID 20585627 2010 The identification of novel associations for hair morphology (rs17646946, near TCHH; rs7349332, near WNT10A; and rs1556547, near OFCC1), freckling (rs2153271, in BNC2), the ability to smell the methanethiol produced after eating asparagus (rs4481887, near OR2M7), and photic sneeze reflex (rs10427255, near ZEB2, and rs11856995, near NR2F2) illustrates the power of the approach.
PMID 20585627 2010 Web-based, participant-driven studies yield novel genetic associations for common traits.
rs10962599 in
BNC2 gene and
Hair Color
PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
rs10756819 in
BNC2 gene and
Malignant neoplasm of ovary
PMID 19648919 2009 A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
rs10810635 in
BNC2 gene and
Melanosis
PMID 29895819 2018 Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.
PMID 20585627 2010 Web-based, participant-driven studies yield novel genetic associations for common traits.
rs10756785 in
BNC2 gene and
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
PMID 30395268 2018 Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
PMID 26211971 2015 A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
PMID 31417091 2019 Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
rs10962612 in
BNC2 gene and
Suntan
PMID 29739929 2018 Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
rs10118611 in
BNC2 gene and
Triglycerides measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs3850445 in
BNC2 gene and
Uric acid measurement (procedure)
PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
rs1538101 in
BNC2 gene and
Velopharyngeal dysfunction
PMID 29855589 2018 GWAS reveals loci associated with velopharyngeal dysfunction.
rs10810603 in
BNC2 gene and
White Blood Cell Count procedure
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs189669683 in
BNC2 gene and
response to bronchodilator
PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.