Gene: BOLL

Alternate names for this Gene: BOULE

Gene Summary: This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q33.1

Description of this Gene: boule homolog, RNA binding protein

Type of Gene: protein-coding

rs700642 in BOLL gene and Allergic Reaction PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

rs700648 in BOLL gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs700641 in BOLL gene and Circadian Rhythms PMID 26835600 2016 GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.

rs700651 in BOLL gene and Intracranial Aneurysm PMID 18997786 2008 Susceptibility loci for intracranial aneurysm in European and Japanese populations.

rs1851779 in BOLL gene and Malignant neoplasm of prostate PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.

rs700655 in BOLL gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.