Gene: BRD1

Alternate names for this Gene: BRL|BRPF1|BRPF2

Gene Summary: This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.33

Description of this Gene: bromodomain containing 1

Type of Gene: protein-coding

rs4468 in BRD1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs138857 in BRD1 gene and Platelet mean volume determination (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs138880 in BRD1 gene and Schizophrenia PMID 23894747 2013 A comprehensive family-based replication study of schizophrenia genes.

rs138834 in BRD1 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.