Gene: BRD2

Alternate names for this Gene: BRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3

Gene Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: bromodomain containing 2

Type of Gene: protein-coding

rs1049526 in BRD2 gene and Crohn Disease PMID 28008999 2016 Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population.

rs1049526 in BRD2 gene and Inflammatory Bowel Diseases PMID 28008999 2016 Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population.

rs1049526 in BRD2 gene and Ulcerative Colitis PMID 28008999 2016 Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population.