Gene: C22orf31

Alternate names for this Gene: HS747E2A|bK747E2.1

Gene Summary:

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.1

Description of this Gene: chromosome 22 open reading frame 31

Type of Gene: protein-coding

Gene: KREMEN1

Alternate names for this Gene: ECTD13|KREMEN|KRM1

Gene Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.1

Description of this Gene: kringle containing transmembrane protein 1

Type of Gene: protein-coding

rs134594 in C22orf31;KREMEN1 gene and Birth Weight PMID 27680694 2016 Genome-wide associations for birth weight and correlations with adult disease.

PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.