Gene: C22orf39

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 22

Location in Chromosome : 22q11.21

Description of this Gene: chromosome 22 open reading frame 39

Type of Gene: protein-coding

Gene: HIRA

Alternate names for this Gene: DGCR1|TUP1|TUPLE1

Gene Summary: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Gene is located in Chromosome: 22

Location in Chromosome : 22q11.21

Description of this Gene: histone cell cycle regulator

Type of Gene: protein-coding