Gene: CARF

Alternate names for this Gene: ALS2CR8|NYD-SP24

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2q33.2

Description of this Gene: calcium responsive transcription factor

Type of Gene: protein-coding

Gene: WDR12

Alternate names for this Gene: YTM1

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.

Gene is located in Chromosome: 2

Location in Chromosome : 2q33.2

Description of this Gene: WD repeat domain 12

Type of Gene: protein-coding

rs114123510 in CARF;WDR12 gene and Coronary Artery Disease PMID 28714975 2017 Association analyses based on false discovery rate implicate new loci for coronary artery disease.

rs149163995 in CARF;WDR12 gene and Migraine Disorders PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs3731695 in CARF;WDR12 gene and Pseudocholinesterase Measurement PMID 21862451 2011 GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.