Gene: CASC8

Alternate names for this Gene: CARLO1|CARLo-1|LINC00860

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: cancer susceptibility 8

Type of Gene: ncRNA

Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

Gene: POU5F1B

Alternate names for this Gene: OCT4-PG1|OCT4PG1|OTF3C|OTF3P1|POU5F1P1|POU5F1P4|POU5FLC20|POU5FLC8

Gene Summary: This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: POU class 5 homeobox 1B

Type of Gene: protein-coding

rs10505477 in CASC8;PCAT1;POU5F1B gene and Adenocarcinoma of large intestine PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

rs10505477 in CASC8;PCAT1;POU5F1B gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

rs10505477 in CASC8;PCAT1;POU5F1B gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs10505477 in CASC8;PCAT1;POU5F1B gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

rs10505477 in CASC8;PCAT1;POU5F1B gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Colorectal Carcinoma PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 17618284 2007 A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 19011631 2008 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Colorectal Neoplasms PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Malignant neoplasm of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Malignant neoplasm of prostate PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 18264096 2008 Multiple loci identified in a genome-wide association study of prostate cancer.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Malignant tumor of colon PMID 28960316 2018 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

PMID 24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 17618283 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Prostate carcinoma PMID 24740154 2014 Genome-wide association scan for variants associated with early-onset prostate cancer.

rs10505477 in CASC8;PCAT1;POU5F1B gene and Prostate specific antigen measurement PMID 28139693 2017 Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.