Gene: CASC8

Alternate names for this Gene: CARLO1|CARLo-1|LINC00860

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: cancer susceptibility 8

Type of Gene: ncRNA

Gene: POU5F1B

Alternate names for this Gene: OCT4-PG1|OCT4PG1|OTF3C|OTF3P1|POU5F1P1|POU5F1P4|POU5FLC20|POU5FLC8

Gene Summary: This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: POU class 5 homeobox 1B

Type of Gene: protein-coding

Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

Gene: CASC21

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

rs13281615 in CASC8;POU5F1B;PCAT1;CASC21 gene and Breast Carcinoma PMID 17529967 2007 Genome-wide association study identifies novel breast cancer susceptibility loci.

PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs13281615 in CASC8;POU5F1B;PCAT1;CASC21 gene and Malignant neoplasm of breast PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

PMID 17529967 2007 Genome-wide association study identifies novel breast cancer susceptibility loci.

rs13281615 in CASC8;POU5F1B;PCAT1;CASC21 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs17464492 in CASC8;POU5F1B;PCAT1;CASC21 gene and Prostate specific antigen measurement PMID 28139693 2017 Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.