Gene: CASC8

Alternate names for this Gene: CARLO1|CARLo-1|LINC00860

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: cancer susceptibility 8

Type of Gene: ncRNA

Gene: POU5F1B

Alternate names for this Gene: OCT4-PG1|OCT4PG1|OTF3C|OTF3P1|POU5F1P1|POU5F1P4|POU5FLC20|POU5FLC8

Gene Summary: This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: POU class 5 homeobox 1B

Type of Gene: protein-coding

Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Adenocarcinoma of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Colorectal Carcinoma PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 19011631 2008 Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

PMID 23266556 2013 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Colorectal Neoplasms PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Malignant neoplasm of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Malignant neoplasm of prostate PMID 18264096 2008 Multiple loci identified in a genome-wide association study of prostate cancer.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Malignant tumor of colon PMID 25990418 2015 A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 18372901 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

rs7014346 in CASC8;POU5F1B;PCAT1 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.