Gene: CASP8AP2

Alternate names for this Gene: CED-4|FLASH|RIP25

Gene Summary: This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6q15

Description of this Gene: caspase 8 associated protein 2

Type of Gene: protein-coding

rs117243822 in CASP8AP2 gene and Glomerular Filtration Rate PMID 31451708 2019 Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.