Gene: CAST
Alternate names for this Gene: BS-17|PLACK
Gene Summary: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene is located in Chromosome: 5
Location in Chromosome : 5q15
Description of this Gene: calpastatin
Type of Gene: protein-coding
Gene: LOC101929710
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