Gene: CBFA2T2
Alternate names for this Gene: EHT|MTGR1|ZMYND3|p85
Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Gene is located in Chromosome: 20
Location in Chromosome : 20q11.21-q11.22
Description of this Gene: CBFA2/RUNX1 partner transcriptional co-repressor 2
Type of Gene: protein-coding