Gene: CBLB

Alternate names for this Gene: Cbl-b|Nbla00127|RNF56

Gene Summary: This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections.

Gene is located in Chromosome: 3

Location in Chromosome : 3q13.11

Description of this Gene: Cbl proto-oncogene B

Type of Gene: protein-coding