Gene: CCR3

Alternate names for this Gene: C C CKR3|CC-CKR-3|CD193|CKR 3|CKR3|CMKBR3

Gene Summary: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: C-C motif chemokine receptor 3

Type of Gene: protein-coding

Gene: LOC105377067

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rs7616215 in CCR3;LOC105377067 gene and Behcet Syndrome PMID 23291587 2013 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.

rs7616215 in CCR3;LOC105377067 gene and Celiac Disease PMID 22057235 2011 Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.