Gene: CCR6

Alternate names for this Gene: BN-1|C-C CKR-6|CC-CKR-6|CCR-6|CD196|CKR-L3|CKRL3|CMKBR6|DCR2|DRY6|GPR29|GPRCY4|STRL22

Gene Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6q27

Description of this Gene: C-C motif chemokine receptor 6

Type of Gene: protein-coding

rs3093009 in CCR6 gene and Asthma PMID 26031901 2016 Genome-wide association study of leukotriene modifier response in asthma.

rs1556413 in CCR6 gene and Rheumatoid Arthritis PMID 20453841 2010 A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.

rs62436827 in CCR6 gene and Triglycerides measurement PMID 24886709 2014 Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.