Gene: CCR7

Alternate names for this Gene: BLR2|CC-CKR-7|CCR-7|CD197|CDw197|CMKBR7|EBI1

Gene Summary: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.2

Description of this Gene: C-C motif chemokine receptor 7

Type of Gene: protein-coding