Gene: CCRL2
Alternate names for this Gene: ACKR5|CKRX|CRAM|CRAM-A|CRAM-B|HCR
Gene Summary: This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
Gene is located in Chromosome: 3
Location in Chromosome : 3p21.31
Description of this Gene: C-C motif chemokine receptor like 2
Type of Gene: protein-coding
rs1015164 in
CCRL2 gene and
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
PMID 31219150 2019 Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
PMID 26553974 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
rs1015164 in
CCRL2 gene and
AIDS, PROGRESSION TO
PMID 31219150 2019 Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
PMID 26553974 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
rs1015164 in
CCRL2 gene and
HIV-1 infection
PMID 26553974 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
rs1015164 in
CCRL2 gene and
HIV-1, RESISTANCE TO
PMID 26553974 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
PMID 31219150 2019 Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
rs1015164 in
CCRL2 gene and
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
PMID 26553974 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
PMID 31219150 2019 Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
rs1015164 in
CCRL2 gene and
Viral Load result
PMID 31219150 2019 Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.