Gene: CCT7

Alternate names for this Gene: CCTETA|CCTH|NIP7-1|TCP1ETA

Gene Summary: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6.

Gene is located in Chromosome: 2

Location in Chromosome : 2p13.2

Description of this Gene: chaperonin containing TCP1 subunit 7

Type of Gene: protein-coding

rs2303907 in CCT7 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs587777929 in CCT7 gene and MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO PMID 24213632 2013 Dysfunctional nitric oxide signalling increases risk of myocardial infarction.