Gene: CD58
Alternate names for this Gene: LFA-3|LFA3|ag3
Gene Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described.
Gene is located in Chromosome: 1
Location in Chromosome : 1p13.1
Description of this Gene: CD58 molecule
Type of Gene: protein-coding
rs1335532 in
CD58 gene and
Multiple Sclerosis
PMID 19525955 2009 Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
PMID 21833088 2011 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
PMID 24234648 2014 No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.