Gene: CD69

Alternate names for this Gene: AIM|BL-AC/P26|CLEC2C|EA1|GP32/28|MLR-3

Gene Summary: This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: CD69 molecule

Type of Gene: protein-coding

rs4763879 in CD69 gene and Diabetes Mellitus, Insulin-Dependent PMID 19430480 2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

PMID 25751624 2015 Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

rs10844706 in CD69 gene and Lymphocyte Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11052877 in CD69 gene and Multiple Sclerosis PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.