Gene: CD86
Alternate names for this Gene: B7-2|B7.2|B70|CD28LG2|LAB72
Gene Summary: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Gene is located in Chromosome: 3
Location in Chromosome : 3q13.33
Description of this Gene: CD86 molecule
Type of Gene: protein-coding