Gene: CDC42EP2

Alternate names for this Gene: BORG1|CEP2

Gene Summary: CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control.

Gene is located in Chromosome: 11

Location in Chromosome : 11q13.1

Description of this Gene: CDC42 effector protein 2

Type of Gene: protein-coding

rs12269727 in CDC42EP2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.