Gene: CDH18

Alternate names for this Gene: CDH14|CDH14L|CDH24

Gene Summary: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5p14.3

Description of this Gene: cadherin 18

Type of Gene: protein-coding

rs115236533 in CDH18 gene and Diastolic blood pressure PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs115236533 in CDH18 gene and Hypertensive disease PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

rs73058713 in CDH18 gene and Leprosy PMID 25642632 2015 Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

rs115236533 in CDH18 gene and Systolic Pressure PMID 28498854 2017 Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.