Gene: CDK8

Alternate names for this Gene: IDDHBA|K35

Gene Summary: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 13

Location in Chromosome : 13q12.13

Description of this Gene: cyclin dependent kinase 8

Type of Gene: protein-coding

rs711214 in CDK8 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs17083838 in CDK8 gene and Pituitary Adenoma PMID 26029870 2015 Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.