Gene: CDKN2B-AS1

Alternate names for this Gene: ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS

Gene Summary: This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960).

Gene is located in Chromosome: 9

Location in Chromosome : 9p21.3

Description of this Gene: CDKN2B antisense RNA 1

Type of Gene: ncRNA

Gene: UBA52P6

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

rs545226 in CDKN2B-AS1;UBA52P6 gene and Glaucoma, Open-Angle PMID 22570617 2012 Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.