Gene: CDKN3

Alternate names for this Gene: CDI1|CIP2|KAP|KAP1

Gene Summary: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q22.2

Description of this Gene: cyclin dependent kinase inhibitor 3

Type of Gene: protein-coding

rs4251631 in CDKN3 gene and Dental caries PMID 23259602 2012 Genome-wide association scan of dental caries in the permanent dentition.

rs144479038 in CDKN3 gene and Liver carcinoma PMID 10987270 2000 Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.