Gene: CDSN

Alternate names for this Gene: HTSS|HTSS1|HYPT2|PSS|PSS1|S

Gene Summary: This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: corneodesmosin

Type of Gene: protein-coding

Gene: PSORS1C1

Alternate names for this Gene: C6orf16|SEEK1

Gene Summary: This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: psoriasis susceptibility 1 candidate 1

Type of Gene: protein-coding

rs1042126 in CDSN;PSORS1C1 gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs1042126 in CDSN;PSORS1C1 gene and AIDS, PROGRESSION TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs386579334 in CDSN;PSORS1C1 gene and Behcet Syndrome PMID 23001997 2012 Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

rs3094214 in CDSN;PSORS1C1 gene and Graves Disease PMID 21900946 2011 Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.

rs1042126 in CDSN;PSORS1C1 gene and HIV-1, RESISTANCE TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs1042126 in CDSN;PSORS1C1 gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs3130981 in CDSN;PSORS1C1 gene and Multiple Sclerosis PMID 17660530 2007 Risk alleles for multiple sclerosis identified by a genomewide study.

rs1042127 in CDSN;PSORS1C1 gene and Rheumatoid Arthritis PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.