Gene: CEBPA
Alternate names for this Gene: C/EBP-alpha|CEBP
Gene Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.11
Description of this Gene: CCAAT enhancer binding protein alpha
Type of Gene: protein-coding
Gene: CEBPA-DT
Alternate names for this Gene: ADINR|CEBPA-AS1
Gene Summary:
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.11
Description of this Gene: CEBPA divergent transcript
Type of Gene: ncRNA
rs28931590 in
CEBPA;CEBPA-DT gene and
Leukemia, Myelocytic, Acute
PMID 12661007 2003 Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.
PMID 23970018 2013 Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
PMID 22138009 2011 NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
PMID 15575056 2004 Mutation of CEBPA in familial acute myeloid leukemia.
PMID 11242107 2001 Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.