Gene: CELA2A

Alternate names for this Gene: AOMS4|ELA2A|PE-1

Gene Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.21

Description of this Gene: chymotrypsin like elastase 2A

Type of Gene: protein-coding

Gene: CELA2B

Alternate names for this Gene: ELA2B

Gene Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.21

Description of this Gene: chymotrypsin like elastase 2B

Type of Gene: protein-coding

rs3820068 in CELA2A;CELA2B gene and Systolic Pressure PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

PMID 28135244 2017 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.