Gene: CELA2A

Alternate names for this Gene: AOMS4|ELA2A|PE-1

Gene Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.21

Description of this Gene: chymotrypsin like elastase 2A

Type of Gene: protein-coding

rs12562037 in CELA2A gene and Pancreatitis, Alcoholic PMID 28754779 2018 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.