Gene: CHD3
Alternate names for this Gene: Mi-2a|Mi2-ALPHA|SNIBCPS|ZFH
Gene Summary: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Gene is located in Chromosome: 17
Location in Chromosome : 17p13.1
Description of this Gene: chromodomain helicase DNA binding protein 3
Type of Gene: protein-coding