Gene: CLCA2

Alternate names for this Gene: CACC|CACC3|CLCRG2|CaCC-3

Gene Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines.

Gene is located in Chromosome: 1

Location in Chromosome : 1p22.3

Description of this Gene: chloride channel accessory 2

Type of Gene: protein-coding

rs2249296 in CLCA2 gene and Crohn Disease PMID 25557950 2015 Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

rs2249296 in CLCA2 gene and IIeocolitis PMID 25557950 2015 Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.