Gene: CLK3
Alternate names for this Gene: PHCLK3|PHCLK3/152
Gene Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9.
Gene is located in Chromosome: 15
Location in Chromosome : 15q24.1
Description of this Gene: CDC like kinase 3
Type of Gene: protein-coding
rs11543198 in
CLK3 gene and
Carcinoma of bladder
PMID 25281661 2015 SNP rs8041357, which is in complete linkage disequilibrium (r(2) = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%).
rs56298217 in
CLK3 gene and
Vital capacity
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.