Gene: CNOT7

Alternate names for this Gene: CAF-1|CAF1|Caf1a|hCAF-1

Gene Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.

Gene is located in Chromosome: 8

Location in Chromosome : 8p22

Description of this Gene: CCR4-NOT transcription complex subunit 7

Type of Gene: protein-coding

Gene: ZDHHC2

Alternate names for this Gene: DHHC2|ZNF372

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8p22

Description of this Gene: zinc finger DHHC-type palmitoyltransferase 2

Type of Gene: protein-coding

rs2959608 in CNOT7;ZDHHC2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.