Gene: CPLX2

Alternate names for this Gene: 921-L|CPX-2|CPX2|Hfb1

Gene Summary: Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5q35.2

Description of this Gene: complexin 2

Type of Gene: protein-coding

rs7448069 in CPLX2 gene and Attention deficit hyperactivity disorder PMID 23527680 2013 Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.

rs55914911 in CPLX2 gene and Cataract, Age-Related Nuclear PMID 24951543 2014 Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.

rs2434237 in CPLX2 gene and Myocardial Infarction PMID 21211798 2011 Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.