Gene: CPM

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

Gene is located in Chromosome: 12

Location in Chromosome : 12q15

Description of this Gene: carboxypeptidase M

Type of Gene: protein-coding

Gene: MDM2

Alternate names for this Gene: ACTFS|HDMX|LSKB|hdm2

Gene Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Gene is located in Chromosome: 12

Location in Chromosome : 12q15

Description of this Gene: MDM2 proto-oncogene

Type of Gene: protein-coding