Gene: CPSF4
Alternate names for this Gene: CPSF30|NAR|NEB-1|NEB1
Gene Summary: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Gene is located in Chromosome: 7
Location in Chromosome : 7q22.1
Description of this Gene: cleavage and polyadenylation specific factor 4
Type of Gene: protein-coding
Gene: ATP5MF
Alternate names for this Gene: ATP5J2|ATP5JL
Gene Summary: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene.
Gene is located in Chromosome: 7
Location in Chromosome : 7q22.1
Description of this Gene: ATP synthase membrane subunit f
Type of Gene: protein-coding
Gene: PTCD1
Alternate names for this Gene: -
Gene Summary: This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene.
Gene is located in Chromosome: 7
Location in Chromosome : 7q22.1
Description of this Gene: pentatricopeptide repeat domain 1
Type of Gene: protein-coding
Gene: ATP5MF-PTCD1
Alternate names for this Gene: ATP5J2-PTCD1
Gene Summary: This locus represents naturally occurring read-through transcription between the ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and PTCD1 (pentatricopeptide repeat domain 1) genes on chromosome 7. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product.
Gene is located in Chromosome: 7
Location in Chromosome : 7q22.1
Description of this Gene: ATP5MF-PTCD1 readthrough
Type of Gene: protein-coding