Gene: CRACR2B

Alternate names for this Gene: EFCAB4A

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: calcium release activated channel regulator 2B

Type of Gene: protein-coding

Gene: CD151

Alternate names for this Gene: GP27|MER2|PETA-3|RAPH|SFA1|TSPAN24

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: CD151 molecule (Raph blood group)

Type of Gene: protein-coding

rs34391416 in CRACR2B;CD151 gene and Bronchitis, Chronic PMID 25241909 2014 For CB COPD relative to smoking controls, we identified a new genome-wide significant locus on chromosome 11p15.5 (rs34391416, OR = 1.93, P = 4.99 × 10-8) as well as significant associations of known COPD SNPs within FAM13A.

rs34391416 in CRACR2B;CD151 gene and Chronic Obstructive Airway Disease PMID 25241909 2014 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.