Gene: CREB3
Alternate names for this Gene: LUMAN|LZIP|sLZIP
Gene Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
Gene is located in Chromosome: 9
Location in Chromosome : 9p13.3
Description of this Gene: cAMP responsive element binding protein 3
Type of Gene: protein-coding
Gene: GBA2
Alternate names for this Gene: AD035|NLGase|SPG46
Gene Summary: This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
Gene is located in Chromosome: 9
Location in Chromosome : 9p13.3
Description of this Gene: glucosylceramidase beta 2
Type of Gene: protein-coding