Gene: CRYM

Alternate names for this Gene: DFNA40|THBP

Gene Summary: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: crystallin mu

Type of Gene: protein-coding

Gene: ANKS4B

Alternate names for this Gene: HARP

Gene Summary:

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: ankyrin repeat and sterile alpha motif domain containing 4B

Type of Gene: protein-coding

rs144039930 in CRYM;ANKS4B gene and Pelvic Organ Prolapse PMID 26545240 2015 Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.