Gene: CTRB1

Alternate names for this Gene: CTRB

Gene Summary: This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein.

Gene is located in Chromosome: 16

Location in Chromosome : 16q23.1

Description of this Gene: chymotrypsinogen B1

Type of Gene: protein-coding

Gene: CTRB2

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 16

Location in Chromosome : 16q23.1

Description of this Gene: chymotrypsinogen B2

Type of Gene: protein-coding

rs8055167 in CTRB1;CTRB2 gene and Pancreatitis, Alcoholic PMID 28754779 2018 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.