Gene: CTRC

Alternate names for this Gene: CLCR|ELA4

Gene Summary: This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.21

Description of this Gene: chymotrypsin C

Type of Gene: protein-coding

rs121909293 in CTRC gene and Hereditary pancreatitis PMID 22942235 2013 Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.

PMID 22580415 2013 Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.

PMID 19453252 2009 Chronic pancreatitis: genetics and pathogenesis.

PMID 22427236 2013 CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?

PMID 25569187 2015 The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population.

PMID 18059268 2008 Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.

PMID 18172691 2008 Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.

PMID 20625975 2011 "Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for ""protective"" (PRSS2) and ""destructive"" (CTRC) genetic factors."

rs545634 in CTRC gene and Pancreatitis, Alcoholic PMID 28754779 2018 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.