Gene: CYP2A7

Alternate names for this Gene: CPA7|CPAD|CYP2A|CYPIIA7|P450-IIA4

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.2

Description of this Gene: cytochrome P450 family 2 subfamily A member 7

Type of Gene: protein-coding

rs28602288 in CYP2A7 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs4079366 in CYP2A7 gene and Smoking PMID 27488534 2016 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

rs4079366 in CYP2A7 gene and Smoking Behaviors PMID 27488534 2016 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

rs28602288 in CYP2A7 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.