Gene: CYP2C8

Alternate names for this Gene: CPC8|CYP2C8DM|CYPIIC8|MP-12/MP-20

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q23.33

Description of this Gene: cytochrome P450 family 2 subfamily C member 8

Type of Gene: protein-coding

rs2275620 in CYP2C8 gene and Arthritis, Gouty PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs1934951 in CYP2C8 gene and Bone necrosis PMID 18594024 2008 Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.

rs1934953 in CYP2C8 gene and Cytokine Measurement PMID 22542470 2012 Genome-wide association study of antibody response to smallpox vaccine.

rs2275620 in CYP2C8 gene and Gout PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs11572169 in CYP2C8 gene and Hormone measurement PMID 21533175 2011 Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.