Gene: CYP3A5

Alternate names for this Gene: CP35|CYPIIIA5|P450PCN3|PCN3

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: cytochrome P450 family 3 subfamily A member 5

Type of Gene: protein-coding

Gene: ZSCAN25

Alternate names for this Gene: ZNF498

Gene Summary: This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: zinc finger and SCAN domain containing 25

Type of Gene: protein-coding

rs41303343 in CYP3A5;ZSCAN25 gene and ASSAY FOR TACROLIMUS PMID 30801552 2019 Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.

rs4646450 in CYP3A5;ZSCAN25 gene and Hormone measurement PMID 21533175 2011 Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

rs12333599 in CYP3A5;ZSCAN25 gene and Platelet Count measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.