Gene: DAB1

Alternate names for this Gene: SCA37

Gene Summary: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.

Gene is located in Chromosome: 1

Location in Chromosome : 1p32.2-p32.1

Description of this Gene: DAB adaptor protein 1

Type of Gene: protein-coding

rs3754260 in DAB1 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs17425707 in DAB1 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs542241509 in DAB1 gene and Cardiac troponin I measurement PMID 31014085 2019 Cardiac Troponin T and Troponin I in the General Population.

rs852787 in DAB1 gene and Coronary Artery Disease PMID 29472232 2018 How rs852787 and its host gene <i>DAB1</i> are linked to CAD needs further studies.

rs6679454 in DAB1 gene and Cytokine Measurement PMID 22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

rs269054 in DAB1 gene and Duration of sleep PMID 30846698 2019 Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

PMID 30804565 2019 Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.

rs17579352 in DAB1 gene and Ischemic stroke PMID 26674333 2016 Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

rs10493240 in DAB1 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs74834332 in DAB1 gene and Memory performance PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

rs527409 in DAB1 gene and Mucocutaneous Lymph Node Syndrome PMID 21221998 2011 Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)).

rs1077424 in DAB1 gene and Non-Small Cell Lung Carcinoma PMID 21866343 2012 The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.

rs3754260 in DAB1 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs11207177 in DAB1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

rs10493251 in DAB1 gene and thyroid function PMID 20826269 2010 A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study.