Gene: DAB2IP

Alternate names for this Gene: AF9Q34|AIP-1|AIP1|DIP1/2

Gene Summary: DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010].

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.2

Description of this Gene: DAB2 interacting protein

Type of Gene: protein-coding

rs10985349 in DAB2IP gene and Aortic Aneurysm, Abdominal PMID 27899403 2017 Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

PMID 20622881 2010 The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10).

rs10818576 in DAB2IP gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10818576 in DAB2IP gene and Coronary Artery Disease PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

rs10985344 in DAB2IP gene and von Willebrand's factor (lab test) PMID 30586737 2019 Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.